Spravato® Treatment for Depression

A supervised, in-office treatment option for adults who have not found relief with traditional antidepressant treatment.

Carolina Psychological Health Services offers Spravato® treatment in a calm, supportive clinical setting. Our REMS‑certified team provides careful monitoring, clear patient education, and coordination with your existing care providers throughout the treatment process.

REMS-Certified Care

Treatment provided in a certified clinical setting.

In-Office Monitoring

Patients are observed during every treatment visit.

Insurance Support

Our team helps navigate benefits and prior authorization steps.

Coordinated Care

We work with your existing providers when appropriate.

What Is Spravato?

SPRAVATO® (esketamine) nasal spray is a prescription medication used in adults for treatment-resistant depression and for depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior in certain treatment settings.

Spravato nasal spray treatment device

Spravato® contains esketamine and is administered as a nasal spray under the supervision of a provider.

  • Prescription nasal spray for eligible adults
  • Administered in a certified medical setting
  • Requires monitoring after each treatment visit
  • Used as part of a broader treatment plan

Because of important safety requirements, Spravato treatment is provided only in certified healthcare settings where patients can be monitored after dosing.

Evidence Behind Spravato® Treatment

Spravato® treatment is supported by clinical trial data and real-world studies involving adults with treatment-resistant depression.

22.5%

Remission at Week 4

In one reported study, 22.5% of patients receiving Spravato® achieved remission after four weeks of treatment.

7.6%

Placebo Comparison

In the same study, 7.6% of patients receiving placebo achieved remission at week four.

24 hrs

Rapid Symptom Improvement

Clinical trials demonstrated improvement in depressive symptoms as early as 24 hours after the first dose compared with placebo.

Important: Individual response varies. Your provider can help determine whether Spravato® may be appropriate based on your symptoms and treatment history.

The Spravato® Treatment Process

Our team guides you through each step, from consultation and insurance review to treatment-day preparation, monitoring, and follow-up.

1

Consultation

We review your history, current symptoms, prior treatments, and whether Spravato® may be appropriate.

2

Insurance Review

Our team helps evaluate coverage requirements and prior authorization steps when applicable.

3

Treatment Planning

If approved, we schedule visits and explain how to prepare for your appointments.

4

Treatment Visit

You self-administer Spravato® nasal spray under supervision in our office.

5

Monitoring & Follow-Up

Patients remain in the office for observation for at least two hours before discharge.

What to Expect During Your Visit

Each visit is designed to be structured, supportive, and carefully monitored so you know what to expect every step of the way.

Spravato treatment visit environment
1

Before Your Appointment

  • Arrange transportation home after treatment
  • Wear comfortable clothing
  • Follow any instructions from your care team
  • Plan to spend approximately 2–3 hours in the office
2

During Your Visit

  • Check-in and clinical review
  • Blood pressure and safety checks
  • Self-administration under supervision
  • Quiet observation period in a comfortable setting
  • Monitoring by staff before discharge
Helpful Tip: Many patients find it helpful to bring headphones, calming music, or an eye mask for the observation period if approved by their provider.

Why Monitoring Is Required

Spravato® treatment is provided only in certified healthcare settings because patients must be monitored after each treatment session for safety.

Observed in Clinic

Spravato® is self-administered under the supervision of a healthcare provider in a certified treatment setting.

Post-Treatment Monitoring

Patients remain in the clinic for observation for at least two hours after dosing before being discharged.

Clinical Safety Checks

Monitoring may include blood pressure checks, observation for sedation or dissociation, and confirmation that you are ready to leave safely.

Insurance Coverage and Referrals

Spravato® treatment often requires insurance verification and prior authorization before treatment can begin. Our team helps guide patients and referring providers through the process so expectations are clear at every step.

Coverage varies by plan, but we assist with benefit verification, coordination with insurance providers, and treatment scheduling once approvals are in place.

Whether you are exploring treatment for yourself, helping a loved one, or referring a patient, our team works to make the process organized, transparent, and supportive.

1

Insurance Verification

We review your benefits and help determine potential coverage and prior authorization requirements.

2

For Patients

Schedule a consultation to discuss eligibility, treatment planning, and next steps.

3

For Referring Providers

Our team coordinates care and can provide referral guidance and communication with your practice.

Success Stories

Hear From Patients Who Have Tried Spravato®

Watch real patient stories and experiences with Spravato® treatment.

Common Questions About Spravato®

We want patients and families to feel informed before getting started. Here are answers to some of the questions we hear most often.

How long does a Spravato® visit take?

Plan for approximately 2–3 hours, including treatment time and the required post-treatment monitoring period.

Can I drive after treatment?

No. Patients should arrange transportation home after each treatment visit and should not drive until the next day after a restful sleep.

Can I take Spravato® at home?

No. Spravato® is administered only in a certified healthcare setting under the supervision of a provider, followed by monitoring after treatment.

Is Spravato® the same as ketamine therapy?

Spravato® contains esketamine and is administered only in certified healthcare settings under REMS requirements. Your provider can help explain whether it may be appropriate for your situation.

Will you work with my current psychiatrist or therapist?

When appropriate, our team coordinates care with your referring psychiatrist, therapist, or other treating provider to support continuity of care.

How do I get started?

The first step is to contact our team for a consultation. We can review eligibility, answer questions about treatment, and discuss insurance and referral steps.

Some patients report symptom relief within hours or days after dosing, though responses vary.

Yes — you must have a ride home. Driving same day is not permitted due to sedation risk.

No — it is only administered in certified in-office settings and requires monitoring.

Many plans provide coverage with prior authorization. Our team will assist.

Your clinician will guide medication adjustments based on your individualized plan.

Spravato® (esketamine) Nasal Spray – Indication

SPRAVATO® (esketamine) nasal spray, in conjunction with an oral antidepressant, is indicated for the treatment of treatment-resistant depression (TRD) in adults. SPRAVATO®, in conjunction with an oral antidepressant, is also indicated for the treatment of depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior.

Important Safety Information

SPRAVATO® can cause serious side effects including sedation, dissociation, respiratory depression, abuse and misuse, and suicidal thoughts and behaviors.

  • Because of the risk of sedation and dissociation, patients must be monitored by a healthcare provider for at least 2 hours after administration.
  • SPRAVATO® is available only through a restricted program called the SPRAVATO REMS program.
  • Patients should not drive or operate machinery until the next day after a restful sleep.

Please see the full Prescribing Information and Medication Guide for additional information.

The TMS Advanced Therapy System is indicated for the treatment of depressive episodes and for decreasing anxiety symptoms for those who may exhibit comorbid anxiety symptoms in adult patients suffering from Major Depressive Disorder (MDD) and who failed to achieve satisfactory improvement from previous antidepressant medication treatment in the current episode.

The TMS Advanced Therapy system is intended to be used as an adjunct for the treatment of adult patients suffering from Obsessive-Compulsive Disorder (OCD).

TMS Advanced Therapy is only available by prescription. A doctor can help decide if TMS Advanced Therapy is right for you. Patients’ results may vary.

The most common side effect is pain or discomfort at or near the treatment site. These events are transient; they occur during the TMS treatment course and do not occur for most patients after the first week of treatment. There is a rare risk of seizure associated with the use of TMS therapy (<0.1% per patient).